Current workflows used for determining the MOA of novel compounds typically entail an array of useful screening assays incorporating a myriad of isolated biological targets. These approaches frequently don't record function while in the dynamic environment in which these targets normally reside. This is especially important for ion channel targets
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The soma of nociceptors are commonly small in diameter in equally the dorsal pathway and in other sensory ganglia. Neurons with tiny soma diameter typically have myelinated Aδ fibers or unmyelinated C fibers, though Aα/β-fibers can be found on cells of greater dimensions. Soma diameter and axon myelination usually are not connected with nocicept
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